07/06/2019

Effect of structure on the digestion of proteins: from animal to plant


  • ORGANISATION/COMPANY
    Laboratoire Léon Brillouin (CEA-CNRS)
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    Physics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    30/11/2019 23:00 - Europe/London
  • LOCATION
    France › Gif-sur-Yvette
    Switzerland › Villigen
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    02/12/2019
  • IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?
    Yes

The thesis will be focused on the physiological process of digestion, studied from a purely physico-chemical point de view (asides of the one of physiologists et nutritionists). It aims at monitoring and modelising unraveling of model food, more or less micro-structured at the smallest scales, comparing animal and plant products like dairy gels and plant proteins.

The experimental part will consist in following the effect of digestive enzymes (gastric and intestinal) on model food, solutions or gels:

- by Small Angle Neutron Scattering and X-ray scattering (SANS & SAXS): in volume on homogeneous samples (neutrons, using contrast variation on mixtures of proteins, lipids or glucids, which have different scattering length density), or at interfaces of films (RX, narrow beam) ;

- by transmission imaging, technique mastered by the Paul Scherrer Institut team: permeation of water in the food piece, evolution of this piece by swelling/deswelling and vanishing of the eddible material;

- by scattering imaging: more difficult but promising, in which PSI is strongly implicated.

A modelisation of all steps, difficult using differential equations, will use agent-based simulations (“distributed artificial intelligence”) in collaboration with an Institut National de la Recherche Agronomique team.

 

Benefits

Training in physics, physico-chemistry, biochemistry and elementary biochemistry and food/ digestion science.

Close connection to food industry and research and development in physico-Chemistry.

Good potential for academic research.

Both laboratories welcome many international staffs including students

Additional comments

Grant will be paid by CNRS (the french national reserach institute) for one 18 months period thesis in France (mainly located in France) , and by Paul Scherrer Institute for the other 18months in Switzerland (mainly located in Switzerland).

Saclay is 25km South of Paris (good Shuttle or train) . Villigen is 35km north of Zurich and 70km east of Basel (nice train and bus connections).

 

 

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

Analytical methods in physico-chemistry and elementary biochemistry.

Biomaterials proteins.

Polymer and biopolymer physics

Physics, matter and radiation

 

Map Information

Work location(s)
1 position(s) available at
Laboratoire Léon Brillouin
France
Gif-sur-Yvette
91191
C.E. Saclay
1 position(s) available at
Paul Scherrer Institute
Switzerland
Villigen
5232
Forschungsstrasse 111

EURAXESS offer ID: 415256

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