ORGANISATION/COMPANYLaboratoire Léon Brillouin (CEA-CNRS)
RESEARCH FIELDBiological sciences › Biological engineeringPhysics
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE30/11/2019 23:00 - Europe/London
LOCATIONFrance › Gif-sur-Yvette
Switzerland › Villigen
TYPE OF CONTRACTTemporary
HOURS PER WEEK35
OFFER STARTING DATE02/12/2019
IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?Yes
The thesis will be focused on the physiological process of digestion, studied from a purely physico-chemical point de view (asides of the one of physiologists et nutritionists). It aims at monitoring and modelising unraveling of model food, more or less micro-structured at the smallest scales, comparing animal and plant products like dairy gels and plant proteins.
The experimental part will consist in following the effect of digestive enzymes (gastric and intestinal) on model food, solutions or gels:
- by Small Angle Neutron Scattering and X-ray scattering (SANS & SAXS): in volume on homogeneous samples (neutrons, using contrast variation on mixtures of proteins, lipids or glucids, which have different scattering length density), or at interfaces of films (RX, narrow beam) ;
- by transmission imaging, technique mastered by the Paul Scherrer Institut team: permeation of water in the food piece, evolution of this piece by swelling/deswelling and vanishing of the eddible material;
- by scattering imaging: more difficult but promising, in which PSI is strongly implicated.
A modelisation of all steps, difficult using differential equations, will use agent-based simulations (“distributed artificial intelligence”) in collaboration with an Institut National de la Recherche Agronomique team.
Training in physics, physico-chemistry, biochemistry and elementary biochemistry and food/ digestion science.
Close connection to food industry and research and development in physico-Chemistry.
Good potential for academic research.
Both laboratories welcome many international staffs including students
Grant will be paid by CNRS (the french national reserach institute) for one 18 months period thesis in France (mainly located in France) , and by Paul Scherrer Institute for the other 18months in Switzerland (mainly located in Switzerland).
Saclay is 25km South of Paris (good Shuttle or train) . Villigen is 35km north of Zurich and 70km east of Basel (nice train and bus connections).
REQUIRED EDUCATION LEVELBiological sciences: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Good
Analytical methods in physico-chemistry and elementary biochemistry.
Polymer and biopolymer physics
Physics, matter and radiation
EURAXESS offer ID: 415256
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