19/07/2019

Post-Doctoral Fellowship IncRNA & Cancer in France

This job offer has expired


  • ORGANISATION/COMPANY
    INSERM DR Grand Ouest
  • RESEARCH FIELD
    Biological sciences
    Medical sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    15/10/2019 12:00 - Europe/London
  • LOCATION
    France › Rennes
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    38h30
  • OFFER STARTING DATE
    15/01/2020
  • IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?
    Yes

In the context of the state regional strategy in Brittany (SAD), our teams benefit from a postdoctoral fellowship to develop and finalize an original discovery that we made in the context of human B cell differentiation into plasma cells. After large genomic screening and functional ad hoc experiments, we identified a pro-oncogenic lncRNA with a high potential of interest for the treatment of Multiple Myeloma and Plasmablastic lymphoproliferative diseases. A patent has been deposited at INSERM Transfert, a private subsidiary of Inserm public research agency, that will accompany our development.

Main activities :

1) To finalize the characterization of molecular effects of this lncRNA using state-of-art genomic tools on human cell lines, primary normal B cells, myeloma primary cells, and

2) To study therapeutic effects of an antisense oligonucleotide that can silence the activity of the specific pro-oncogenic lncRNA.

Associates activities :

This project is part of a collaboration and a gathering and sharing of skills between several partners who share a common sense of purpose. Partners: Thierry Fest (UMR INSERM 1236, Rennes); Gilles Salbert (UMR CNRS 6290, IGDR, Rennes); Jérôme Moreaux (CNRS UMR 9002-CNRS-UM - Institute of Human Genetics & CHU de Montpellier); and David Gilot (UMR CNRS 6290, IGDR, Rennes). Direct supervision of the project will be done by David Gilot and Thierry Fest and the work done in both labs, localized in the same campus, that have complementary tools and skills: pharmaceutical skills and lncRNA expertise for the first one, and primary B-cell biology plus functional analyses for the second. English is the commonly used language in the lab.

 

 

Additional comments

Duration : initial contract of 24 months

Salary : 2200 to 2500 € per month, depending on previous experience

Envisaged start date : January 2nd/2020

Web site for additional job details

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4
  • RESEARCH FIELD
    Medical sciencesOther
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: PhD or equivalent
    Medical sciences: PhD or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

To have stayed less than 18 months in France in the last 3 years. Position open for French, for people form European Community and people outside Europe

 

 

 

 

Specific Requirements

The post-doctoral candidate will have excellent knowledge on cell and molecular biology, have experience in RNA biology, and good knowledge in gene regulation analysis. Would be appreciate knowledge in bioinformatic and B cell immunology.

Fields: Cancer or RNA biology

 

 

 

 

Work location(s)
1 position(s) available at
UMR INSERM 1236
France
Rennes
35043
Faculté de médecine - Bâtiment 2 - Etage 1 2 avenue du professeur Léon Bernard - CS 34317

EURAXESS offer ID: 428867

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