ORGANISATION/COMPANYINSERM DR Grand Ouest
RESEARCH FIELDBiological sciencesMedical sciences
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE15/10/2019 12:00 - Europe/London
LOCATIONFrance › Rennes
TYPE OF CONTRACTTemporary
HOURS PER WEEK38h30
OFFER STARTING DATE15/01/2020
IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?Yes
In the context of the state regional strategy in Brittany (SAD), our teams benefit from a postdoctoral fellowship to develop and finalize an original discovery that we made in the context of human B cell differentiation into plasma cells. After large genomic screening and functional ad hoc experiments, we identified a pro-oncogenic lncRNA with a high potential of interest for the treatment of Multiple Myeloma and Plasmablastic lymphoproliferative diseases. A patent has been deposited at INSERM Transfert, a private subsidiary of Inserm public research agency, that will accompany our development.
Main activities :
1) To finalize the characterization of molecular effects of this lncRNA using state-of-art genomic tools on human cell lines, primary normal B cells, myeloma primary cells, and
2) To study therapeutic effects of an antisense oligonucleotide that can silence the activity of the specific pro-oncogenic lncRNA.
Associates activities :
This project is part of a collaboration and a gathering and sharing of skills between several partners who share a common sense of purpose. Partners: Thierry Fest (UMR INSERM 1236, Rennes); Gilles Salbert (UMR CNRS 6290, IGDR, Rennes); Jérôme Moreaux (CNRS UMR 9002-CNRS-UM - Institute of Human Genetics & CHU de Montpellier); and David Gilot (UMR CNRS 6290, IGDR, Rennes). Direct supervision of the project will be done by David Gilot and Thierry Fest and the work done in both labs, localized in the same campus, that have complementary tools and skills: pharmaceutical skills and lncRNA expertise for the first one, and primary B-cell biology plus functional analyses for the second. English is the commonly used language in the lab.
Duration : initial contract of 24 months
Salary : 2200 to 2500 € per month, depending on previous experience
Envisaged start date : January 2nd/2020
Web site for additional job details
Required Research Experiences
RESEARCH FIELDBiological sciences › Biology
YEARS OF RESEARCH EXPERIENCE1 - 4
RESEARCH FIELDMedical sciences › Other
YEARS OF RESEARCH EXPERIENCE1 - 4
REQUIRED EDUCATION LEVELBiological sciences: PhD or equivalentMedical sciences: PhD or equivalent
REQUIRED LANGUAGESENGLISH: Good
To have stayed less than 18 months in France in the last 3 years. Position open for French, for people form European Community and people outside Europe
The post-doctoral candidate will have excellent knowledge on cell and molecular biology, have experience in RNA biology, and good knowledge in gene regulation analysis. Would be appreciate knowledge in bioinformatic and B cell immunology.
Fields: Cancer or RNA biology
EURAXESS offer ID: 428867
The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.
Please contact firstname.lastname@example.org if you wish to download all jobs in XML.