01/11/2021

14 PhD positions available for research on Allostery in Drug Discovery


You want to participate in a training programme in and beyond the fields of physical chemistry of biological systems, theoretical and computational chemistry, biological chemistry, biochemistry, targeted drug delivery/discovery and medicinal chemistry?

14 Early Stage Researcher (ESR) positions are available within the EU-funded Marie Skłodowska Curie Innovative Training Network on Allostery in Drug Discovery (ALLODD).

The ALLODD project is a collaboration between 13 academic and industrial organizations with 14 ESR/PhD students in total. The aim of ALLODD is to train a new generation of scientists to exploit the concept of allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems.

Open Positions

  1. "Development of a computational methodology to detect allosteric pathways in proteins and application in drug discovery"
  2. "Biophysical characterization of allosteric interactions using NMR spectroscopy"
  3. "Allosteric modulators of Fbw7 E3 ligase"
  4. "Excitation energy transfer applied to drug design"
  5. "Allosteric drugs development for receptor mosaics"
  6. "Structural elucidation of allosteric mechanisms in G-protein coupled receptors or other membrane proteins by structural biology methods"
  7. "Design and synthesis of covalent allosteric probes"
  8. "Design and synthesis of allosteric phosphatase inhibitors"
  9. "Identification of target binding sites using HDX MS and off-targets using Proteome Thermo Profiling"
  10. "Computer-aided drug discovery of GPCR allosteric modulators"
  11. "Rational design of positive and negative allosteric modulators of pLGICs"
  12. "Identification of new targets from screening using biochemical and cell based assays"
  13. "Validation and prospective application of allosteric binding site detection and ligand identification"
  14. "Allosteric modulation of GPCRs at the protein – membrane interface"

Benefits

We are offering a competitive, interdisciplinary environment with a track record of intense mutual collaboration. In addition to the individual training-through-research, our programme includes further elements such as workshops, summer schools, internships and secondments to the partners’ laboratories.

Eligibility

The following eligibility rules apply for participation in a Marie Skłodowska Curie Innovative Training Network: Applicants must be in the first 4 years after obtaining their Master's degree and/or Bachelor’s degree and must not have resided or carried out their main activity (work, studies, etc.) in the host country for more than 12 months in the 3 years immediately before the recruitment date. In addition, local regulations of the host countries may apply. The salary is based on standard living, mobility and family allowances which are adapted to the respective country of recruitment.

We are looking for highly motivated and talented researchers at the beginning of their carrier that are interested in the aforementioned scientific fields based on the specific requirements noted below for each position. Excellent command of spoken and written English, communication skills as well as team spirit are essential.

Deadline: 31 January 2021

The earliest starting date will be 1 November 2021. The latest will be 1 September 2022.

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